Etude de l'activité anti-inflammatoire de quelques dérivés de l'acide salicylique

Abstract

The objective of this study is the evaluation of the anti-inflammatory activity of salicylic acid derivatives in vitro by 2 methods : The test of the inhibition of the denaturation of proteins and the test of the stabilization of the membrane of human red blood cells expressed as the percentages of hemolysis of red blood cells. The results obtained showed that some products tested have a greater ability to inhibit RBC hemolysis compared to aspirin used as a reference, in particular the compounds : K104, K127, b7 and b12. These results suggest that these compounds exhibit significant anti-inflammatory activity by inhibiting the hemolysis of red blood cells compared to aspirin at the same concentration 1000 μg / ml. The comparative study of the results obtained on the model of the inflammatory leg in vivo with the results obtained on the same compounds in vitro show a large approach in the activity of the two models studied, in particular the 2 compounds K104 and b12 which exhibit a better activity whether in vivo or in vitro. The results obtained from the effect of our compounds for the 2 series studied or by the negative control and the reference compound, diclofenac, did not show a significant difference in the measurement of the absorbance in the test for the denaturation of protein.