Synthesis of some Stilbene derivatives and the removal of Triphenylphosphineoxide (TPPO) by precipitation, Complexation with ZnCl2 and dry Column Vacum Chromatography (DCVC)

Abstract

In this thesis, we synthesized five alkenes according to the Wittig reaction, and we tried to develop the best method to remove TPPO by applying three different processes and comparing their efficiency, with the aim to apply it in future research work based on Wittig reaction and Corey-Fuchs reaction which both generate TPPO as a side product. These methods are precipitation of TPPO in cyclohexane, or complexation with zinc chloride for 18 hours at room temperature or for two hours. at reflux and finally separation by chromatography (DCVC). It has been found that DCVC is the most effective in removing TPPO, so we can adopt it in future research.