Résumé:
Abstract
Diclofenac is an important non-steroidal anti-inflammatory drug (NSAID) that is considered to be an
environmental micropollutant. The aim of this work was to study its biodegradation (using free and
immobilized cells) in order to assess the fate of these phannaceuticals in the environment. Sixteen
strains were tested for their capacity to resist diclofenac; whereas only two strains have been
identified . This identification shows that the two strains belong to the Genus Acinetobacter.
According to HPLC chromatograms, no peaks were observed corresponding to metabolites during
biodegradation test.
In order to select factors that affect cells growth Plackett-Bunnan design were used.
Results showed that pH seems to be the most significant factor affecting cell growth.
